Runes can be used to create Crafted Items.
Runes are listed from most common to least common: El, Eld, Tir, Nef, Eth, Ith, Tal, Ral, Ort, Amn, Shael, and Thul are pretty common. You receive Ral, Ort and Tal as a quest reward in Act V. You shouldn't trade much for them since you can find them pretty easily with regular play. Don't fall for the "1 Shael or/+ Amn for 1 SOJ" scam. You can find these yourself. If you're thinking of freeing up space, throw those Runes away and save all Runes from Sol through Zod.
Listed from most common to most rare: Sol, Dol, Hel, Io, Lum, Ko, Fal, Lem, Pul, Um. Some of these Runes are more valuable than others depending on their stats and how they are used in Rune Words or Crafted Recipes.
Extremely Rare Runes
Listed from most common to most rare: Mal, Ist, Gul, Vex, Ohm, Lo, Sur, Ber, Jah, Cham, Zod. Trade these for good stuff!
If the player puts certain combinations of Runes in the correct order into an item with exactly that number of sockets and of the correct item type, the item's name will change into a "unique" name, displayed in gold, and the item will acquire extra powers, depending on the "rune word" that was used.
|El||+50 To Attack Rating, +1 Light Radius||+15 Defense, +1 To Light Radius||11|
|Eld||+75% Damage To Undead, +50 Attack Rating Against Undead||15% Slower Stamina Drain/7% Increased Chance of Blocking(Shields)||11|
|Tir||+2 To Mana After Each Kill||+2 To Mana After Each Kill||13|
|Nef||Knockback||+30 Defense Vs. Missile||13|
|Eth||-25% To Target Defense||Regenerate Mana 15%||15|
|Ith||+9 To Maximum Damage||15% Damage Taken Goes to Mana||15|
|Tal||+75 Poison Damage Over 5 Seconds||Poison Resist 30%/Poison Resist 35%(Shields)||17|
|Ral||Adds 5-30 Fire Damage||Fire Resist 30%/Fire Resist 35%(Shields)||19|
|Ort||Adds 1-50 Lightning Damage||Lightning Resist 30%/Lightning Resist 35%(Shields)||21|
|Thul||Adds 3-14 Cold Damage - 3 Second Duration||Cold Resist 30%/Cold Resist 35%(Shields)||23|
|Amn||7% Life Stolen Per Hit||Attacker Takes Damage of 14||25|
|Sol||+9 To Minimum Damage||Damage Reduced By 7||27|
|Shael||20% Increased Attack Speed||20% Faster Hit Recovery/20% Faster Block Rate(Shields)||29|
|Dol||Hit Causes Monster To Flee 25%||Replenish Life +7||31|
|Hel||Requirements -20%||Requirements -15%||-|
|Io||+10 To Vitality||+10 To Vitality||35|
|Lum||+10 To Energy||+10 To Energy||37|
|Ko||+10 To Dexterity||+10 To Dexterity||39|
|Fal||+10 To Strength||+10 To Strength||41|
|Lem||75% Extra Gold From Monsters||50% Extra Gold From Monsters||43|
|Pul||+75% Damage To Demons, +100 Attack Rating Against Demons||+30% Enhanced Defense||45|
|Um||25% Chance of Open Wounds||All Resistances +15(Armor/Helms) +22(Shields)||47|
|Mal||Prevent Monster Heal||Magic Damage Reduced By 7||49|
|Ist||30% Better Chance of Getting Magic Items||25% Better Chance of Getting Magic Items||51|
|Gul||20% Bonus To Attack Rating||5% To Maximum Poison Resist||53|
|Vex||7% Mana Stolen Per Hit||5% To Maximum Fire Resist||55|
|Ohm||+50% Enhanced Damage||5% To Maximum Cold Resist||57|
|Lo||20% Deadly Strike||5% To Maximum Lightning Resist||59|
|Sur||Hit Blinds Target||Maximum Mana 5%/+50 To Mana (Shields)||61|
|Ber||20% Chance of Crushing Blow||Damage Reduced by 8%||63|
|Jah||Ignore Target's Defense||Increase Maximum Life 5%/+50 Life (Shields)||65|
|Cham||Freeze Target +3||Cannot Be Frozen||67|